8QF2

Beta-L-Arabinofurano-cyclitol Aziridines are Cysteine-directed Broad-spectrum Inhibitors and Activity-based Probes for Retaining Beta-L-arabinofuranosidases

This is a non-PDB format compatible entry.

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000272	biological_process	polysaccharide catabolic process
A	0005975	biological_process	carbohydrate metabolic process
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0046872	molecular_function	metal ion binding
A	0102478	molecular_function	beta-L-arabinofuranosidase activity

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	1
Details	ACT_SITE: Proton donor/acceptor => ECO:0000305|PubMed:24680821, ECO:0000305|DOI:10.4172/2155-9821.1000171

Chain	Residue	Details
A	GLU322

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site_id	SWS_FT_FI2
Number of Residues	1
Details	ACT_SITE: Nucleophile; S-glycosyl-cysteine intermediate => ECO:0000305|PubMed:24680821, ECO:0000305|DOI:10.4172/2155-9821.1000171

Chain	Residue	Details
A	CYS417

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site_id	SWS_FT_FI3
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:24680821, ECO:0000269|DOI:10.4172/2155-9821.1000171, ECO:0007744|PDB:3WKX, ECO:0007744|PDB:3WRG

Chain	Residue	Details
A	HIS142
A	ASP192
A	HIS270
A	GLU322

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site_id	SWS_FT_FI4
Number of Residues	4
Details	BINDING: BINDING => ECO:0000269|PubMed:24680821, ECO:0000269|DOI:10.4172/2155-9821.1000171, ECO:0007744|PDB:3WKX, ECO:0007744|PDB:3WRE, ECO:0007744|PDB:3WRG

Chain	Residue	Details
A	GLU338
A	CYS340
A	CYS417
A	CYS418

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