8QED

S. cerevisia Niemann-Pick type C protein NCR1 in LMNG at pH 5.5

Summary for 8QED

Entry DOI	10.2210/pdb8qed/pdb
Related	8QEB 8QEC 8QEE
EMDB information	18350 18351 18352 18353
Descriptor	NPC intracellular sterol transporter 1-related protein 1, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ERGOSTEROL, ... (4 entities in total)
Functional Keywords	sterol transport, vacuole, lysosome, lipid transport, membrane protein
Biological source	Saccharomyces cerevisiae (baker's yeast)
Total number of polymer chains	1
Total formula weight	135980.03
Authors	Frain, K.M.,Nel, L.,Dedic, E.,Olesen, E.,Stokes, D.,Panyella Pedersen, B. (deposition date: 2023-08-31, release date: 2023-10-18, Last modification date: 2024-04-17)
Primary citation	Frain, K.M.,Dedic, E.,Nel, L.,Bohush, A.,Olesen, E.,Thaysen, K.,Wustner, D.,Stokes, D.L.,Pedersen, B.P. Conformational changes in the Niemann-Pick type C1 protein NCR1 drive sterol translocation. Proc.Natl.Acad.Sci.USA, 121:e2315575121-e2315575121, 2024 Cited by PubMed: 38568972 DOI: 10.1073/pnas.2315575121 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.27 Å)

Structure validation