8Q9P

Crystal Structure of the MADS-box/MEF2 Domain of MEF2D bound to dsDNA and HDAC5 deacetylase binding motif

Summary for 8Q9P

Entry DOI	10.2210/pdb8q9p/pdb
Descriptor	HDAC5 (histone deacetylase 5) binding motif peptide: TRP-GLY-SER-GLY-GLU-VAL-LYS-LEU-ARG-LEU-GLN-GLU-PHE-LEU-LEU-SER-LYS-SER, MEF2D protein, MADS box dsDNA fw: AACTATTTATAAGA, ... (5 entities in total)
Functional Keywords	transcriptional repressor, transcription
Biological source	Homo sapiens (Human) More
Total number of polymer chains	5
Total formula weight	33144.13
Authors	Chinellato, M.,Carli, A.,Perin, S.,Mazzocato, Y.,Biondi, B.,Di Giorgio, E.,Brancolini, C.,Angelini, A.,Cendron, L. (deposition date: 2023-08-20, release date: 2024-04-17)
Primary citation	Chinellato, M.,Perin, S.,Carli, A.,Lastella, L.,Biondi, B.,Borsato, G.,Di Giorgio, E.,Brancolini, C.,Cendron, L.,Angelini, A. Folding of Class IIa HDAC Derived Peptides into alpha-helices Upon Binding to Myocyte Enhancer Factor-2 in Complex with DNA. J.Mol.Biol., 436:168541-168541, 2024 Cited by PubMed: 38492719 DOI: 10.1016/j.jmb.2024.168541 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation