8Q61
Co-crystal structure of human AKT2 with compound 3
Summary for 8Q61
Entry DOI | 10.2210/pdb8q61/pdb |
Descriptor | RAC-beta serine/threonine-protein kinase, 6-[4-(1-azanyl-3-methyl-3-oxidanyl-cyclobutyl)phenyl]-7-phenyl-1-propyl-pyrido[2,3-b][1,4]oxazin-2-one, GLYCEROL, ... (6 entities in total) |
Functional Keywords | protein kinase inhibitor complex, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 1 |
Total formula weight | 56990.57 |
Authors | |
Primary citation | Page, N.,Wappett, M.,O'Dowd, C.R.,O'Rourke, M.,Gavory, G.,Zhang, L.,Rountree, J.S.S.,Jordan, L.,Barker, O.,Gibson, H.,Boyd, C.,Feutren-Burton, S.,McLean, E.,Trevitt, G.,Harrison, T. Identification and development of a subtype-selective allosteric AKT inhibitor suitable for clinical development. Sci Rep, 12:15715-, 2022 Cited by PubMed: 36127435DOI: 10.1172/JCI41680 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.32 Å) |
Structure validation
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