8Q40
Crystal structure of cA4 activated Can2 in complex with a cleaved DNA substrate
Summary for 8Q40
| Entry DOI | 10.2210/pdb8q40/pdb |
| Related PRD ID | PRD_002431 |
| Descriptor | DUF1887 family protein, DNA (5'-D(*TP*CP*A)-3'), Cyclic tetraadenosine monophosphate (cA4), ... (5 entities in total) |
| Functional Keywords | can2, cyclic oligoadenylates, ca4, carf, crispr ancillary nuclease, protein-dna complex, dna binding protein |
| Biological source | Thermoanaerobacter brockii subsp. finnii Ako-1 More |
| Total number of polymer chains | 5 |
| Total formula weight | 109763.15 |
| Authors | Jungfer, K.,Sigg, A.,Jinek, M. (deposition date: 2023-08-04, release date: 2023-11-22, Last modification date: 2024-01-24) |
| Primary citation | Jungfer, K.,Sigg, A.,Jinek, M. Substrate selectivity and catalytic activation of the type III CRISPR ancillary nuclease Can2. Nucleic Acids Res., 52:462-473, 2024 Cited by PubMed: 38033326DOI: 10.1093/nar/gkad1102 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.21 Å) |
Structure validation
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