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8Q40

Crystal structure of cA4 activated Can2 in complex with a cleaved DNA substrate

Entity
Entity IDChain IDDescriptionTypeChain lengthFormula weightNumber of moleculesDB Name (Accession)Biological sourceDescriptive keywords
1A, B
(A, B)
DUF1887 family proteinpolymer43951400.52UniProt (E8URK0)Thermoanaerobacter brockii subsp. finnii Ako-1
2C, D
(D, C)
DNA (5'-D(*TP*CP*A)-3')polymer92707.82Thermoanaerobacter brockii subsp. finnii Ako-1
3E
(X)
Cyclic tetraadenosine monophosphate (cA4)polymer41271.91BIRD (PRD_002431)synthetic construct
4F, G, H, I, J
(A, B, D)
MANGANESE (II) IONnon-polymer54.95Chemie (MN)
5K, L, M, N, O
(A, B, D, C, X)
waterwater18.0175Chemie (HOH)
Sequence modifications
A, B: 1 - 437 (UniProt: E8URK0)
PDBExternal DatabaseDetails
Ser -1-expression tag
Asn 0-expression tag
Sequence viewer
Contents of the asymmetric unit
PolymersNumber of chains5
Total formula weight109488.5
Non-Polymers*Number of molecules5
Total formula weight274.7
All*Total formula weight109763.2
*Water molecules are not included.

247947

PDB entries from 2026-01-21

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