8Q2G

X-ray structure of LysECD7 endolysin against Gram-negative bacteria

Summary for 8Q2G

• Entry DOI: 10.2210/pdb8q2g/pdb
• Descriptor: Peptidoglycan L-alanyl-D-glutamate endopeptidase (2 entities in total)
• Functional Keywords: endolysins, bacteriophage lytic enzymes, gram-negative bacteria, antibacterial therapy, antimicrobial agents, antibiotic, antimicrobial protein
• Biological source: Escherichia phage ECD7
• Total number of polymer chains: 1
• Total formula weight: 16117.48

Authors

Prudnikova, T.,Grinkevich, P.,Vasina, D.V. (deposition date: 2023-08-02, release date: 2024-07-31, Last modification date: 2024-08-07)

Primary citation

Vasina, D.V.,Antonova, N.P.,Gushchin, V.A.,Aleshkin, A.V.,Fursov, M.V.,Fursova, A.D.,Gancheva, P.G.,Grigoriev, I.V.,Grinkevich, P.,Kondratev, A.V.,Kostarnoy, A.V.,Lendel, A.M.,Makarov, V.V.,Nikiforova, M.A.,Pochtovyi, A.A.,Prudnikova, T.,Remizov, T.A.,Shevlyagina, N.V.,Siniavin, A.E.,Smirnova, N.S.,Terechov, A.A.,Tkachuk, A.P.,Usachev, E.V.,Vorobev, A.M.,Yakimakha, V.S.,Yudin, S.M.,Zackharova, A.A.,Zhukhovitsky, V.G.,Logunov, D.Y.,Gintsburg, A.L.
Development of novel antimicrobials with engineered endolysin LysECD7-SMAP to combat Gram-negative bacterial infections.
J.Biomed.Sci., 31:75-75, 2024

PubMed Abstract: Among the non-traditional antibacterial agents in development, only a few targets critical Gram-negative bacteria such as carbapenem-resistant Pseudomonas aeruginosa, Acinetobacter baumannii or cephalosporin-resistant Enterobacteriaceae. Endolysins and their genetically modified versions meet the World Health Organization criteria for innovation, have a novel mode of antibacterial action, no known bacterial cross-resistance, and are being intensively studied for application against Gram-negative pathogens.

PubMed: 39044206
DOI: 10.1186/s12929-024-01065-y

Experimental method

X-RAY DIFFRACTION (2.49 Å)