8PXV

Targeting extended blood antigens by Akkermansia muciniphila enzymes unveils a missing link for generating universal donor blood

Summary for 8PXV

Entry DOI	10.2210/pdb8pxv/pdb
Related PRD ID	PRD_900004
Descriptor	Beta-N-acetylhexosaminidase, beta-D-galactopyranose-(1-4)-beta-D-glucopyranose, GLYCEROL, ... (5 entities in total)
Functional Keywords	beta-hexosaminidase, akkermansia muciniphila, galnac-b converting, cbm, hydrolase
Biological source	Akkermansia muciniphila
Total number of polymer chains	3
Total formula weight	220726.70
Authors	Weikum, J.,Jensen, M.,Abou Hachem, M.,Morth, J.P. (deposition date: 2023-07-24, release date: 2024-02-28, Last modification date: 2024-05-15)
Primary citation	Jensen, M.,Stenfelt, L.,Ricci Hagman, J.,Pichler, M.J.,Weikum, J.,Nielsen, T.S.,Hult, A.,Morth, J.P.,Olsson, M.L.,Abou Hachem, M. Akkermansia muciniphila exoglycosidases target extended blood group antigens to generate ABO-universal blood. Nat Microbiol, 2024 Cited by PubMed: 38684911 DOI: 10.1038/s41564-024-01663-4 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.5 Å)

Structure validation