8PXV

Targeting extended blood antigens by Akkermansia muciniphila enzymes unveils a missing link for generating universal donor blood

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C	Beta-N-acetylhexosaminidase	polymer	655	73309.0	3	UniProt (B2UN02) Pfam (PF02838) Pfam (PF00728) In PDB	Akkermansia muciniphila
2	E, F	beta-D-galactopyranose-(1-4)-beta-D-glucopyranose	branched		342.3	2	In PDB BIRD (PRD_900004) GlyTouCan (G84224TW)
3	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
4	C	SODIUM ION	non-polymer		23.0	1	Chemie (NA)
5		water	water		18.0	456	Chemie (HOH)

Sequence modifications

A, B, C: 2 - 647 (UniProt: B2UN02)

PDB	External Database	Details
Met 1	-	initiating methionine
Leu 648	-	expression tag
Glu 649	-	expression tag
His 650	-	expression tag
His 651	-	expression tag
His 652	-	expression tag
His 653	-	expression tag
His 654	-	expression tag
His 655	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	3
	Total formula weight	219927.0
Branched	Number of molecules	2
	Total formula weight	684.6
Non-Polymers*	Number of molecules	2
	Total formula weight	115.1
All*	Total formula weight	220726.7

*Water molecules are not included.