8PQI

PDGFRA T674I mutant kinase domain in complex with avapritinib derivative 9

Summary for 8PQI

• Entry DOI: 10.2210/pdb8pqi/pdb
• Descriptor: Platelet-derived growth factor receptor alpha, (1~{S})-~{N}-ethyl-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine, DI(HYDROXYETHYL)ETHER, ... (4 entities in total)
• Functional Keywords: pdgfra protein kinase, avapritinib, inhibitor, tyrosine kinase, transmembrane receptor, platelet-derived growth factor receptor alpha, pdgf, platelet-derived growth factor, gist, gastrointestinal stromal tumors, gatekeeper mutant, p16234, transferase
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 1
• Total formula weight: 40859.10

Authors

Teuber, A.,Kleinboelting, S.,Mueller, M.P.,Rauh, D. (deposition date: 2023-07-11, release date: 2023-12-27, Last modification date: 2024-03-13)

• Primary citation: Teuber, A.,Schulz, T.,Fletcher, B.S.,Gontla, R.,Muhlenberg, T.,Zischinsky, M.L.,Niggenaber, J.,Weisner, J.,Kleinbolting, S.B.,Lategahn, J.,Sievers, S.,Muller, M.P.,Bauer, S.,Rauh, D.; Avapritinib-based SAR studies unveil a binding pocket in KIT and PDGFRA.; Nat Commun, 15:63-63, 2024; PubMed: 38167404; DOI: 10.1038/s41467-023-44376-8

Experimental method

X-RAY DIFFRACTION (2.6 Å)