8PQI
PDGFRA T674I mutant kinase domain in complex with avapritinib derivative 9
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Platelet-derived growth factor receptor alpha | polymer | 352 | 40226.4 | 1 | UniProt (P16234) Pfam (PF07714) In PDB | Homo sapiens (human) | PDGF-R-alpha,PDGFR-alpha,Alpha platelet-derived growth factor receptor,Alpha-type platelet-derived growth factor receptor,CD140 antigen-like family member A,CD140a antigen,Platelet-derived growth factor alpha receptor,Platelet-derived growth factor receptor 2,PDGFR-2 |
2 | A | (1~{S})-~{N}-ethyl-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2,1-f][1,2,4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine | non-polymer | 526.6 | 1 | Chemie (9OO) | |||
3 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
4 | water | water | 18.0 | 8 | Chemie (HOH) |
Sequence modifications
A: 550 - 768 (UniProt: P16234)
A: 769 - 973 (UniProt: P16234)
PDB | External Database | Details |
---|---|---|
Ile 674 | Thr 674 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 40226.4 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 632.7 | |
All* | Total formula weight | 40859.1 |