8PPM

IL-12Rb1 neutralizing Fab4, crystal kappa variant

Summary for 8PPM

• Entry DOI: 10.2210/pdb8ppm/pdb
• Related: 8C7M 8ODX
• Descriptor: Fab4 heavy chain, Fab4 Light chain, crystal kappa variant, POTASSIUM ION, ... (4 entities in total)
• Functional Keywords: antibody, fab fragment, designed crystal contact, immunosuppressant
• Biological source: Homo sapiens x Mus musculus hybrid cell line; More
• Total number of polymer chains: 2
• Total formula weight: 48104.51

Authors

Bloch, Y.,Savvides, S.N. (deposition date: 2023-07-07, release date: 2024-02-07, Last modification date: 2024-05-01)

• Primary citation: Bloch, Y.,Felix, J.,Merceron, R.,Provost, M.,Symakani, R.A.,De Backer, R.,Lambert, E.,Mehdipour, A.R.,Savvides, S.N.; Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23.; Nat.Struct.Mol.Biol., 31:591-597, 2024; PubMed: 38287195; DOI: 10.1038/s41594-023-01190-6

Experimental method

X-RAY DIFFRACTION (2.03 Å)