8PPM
IL-12Rb1 neutralizing Fab4, crystal kappa variant
Summary for 8PPM
Entry DOI | 10.2210/pdb8ppm/pdb |
Related | 8C7M 8ODX |
Descriptor | Fab4 heavy chain, Fab4 Light chain, crystal kappa variant, POTASSIUM ION, ... (4 entities in total) |
Functional Keywords | antibody, fab fragment, designed crystal contact, immunosuppressant |
Biological source | Homo sapiens x Mus musculus hybrid cell line More |
Total number of polymer chains | 2 |
Total formula weight | 48104.51 |
Authors | Bloch, Y.,Savvides, S.N. (deposition date: 2023-07-07, release date: 2024-02-07, Last modification date: 2024-05-01) |
Primary citation | Bloch, Y.,Felix, J.,Merceron, R.,Provost, M.,Symakani, R.A.,De Backer, R.,Lambert, E.,Mehdipour, A.R.,Savvides, S.N. Structures of complete extracellular receptor assemblies mediated by IL-12 and IL-23. Nat.Struct.Mol.Biol., 31:591-597, 2024 Cited by PubMed: 38287195DOI: 10.1038/s41594-023-01190-6 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.03 Å) |
Structure validation
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