8PPE
Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with DL-6-deoxy-6-phosphoryloxymethyl-scyllo-inositol 1,2,4-trisphosphate/ADP/Mn
Summary for 8PPE
Entry DOI | 10.2210/pdb8ppe/pdb |
Related | 8PP8 8PP9 8PPA 8PPB 8PPC 8PPD |
Descriptor | Inositol-trisphosphate 3-kinase A, ADENOSINE-5'-DIPHOSPHATE, DL-6-deoxy-6-phosphoryloxymethyl-scyllo-inositol 1,2,4-trisphosphate, ... (6 entities in total) |
Functional Keywords | inositol polyphosphate, insp, inositol kinase, ip3k, calcium, insp3, ip3, ipk, ip3 3-k, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 65839.11 |
Authors | Marquez-Monino, M.A.,Gonzalez, B. (deposition date: 2023-07-07, release date: 2024-02-28, Last modification date: 2024-03-27) |
Primary citation | Marquez-Monino, M.A.,Ortega-Garcia, R.,Whitfield, H.,Riley, A.M.,Infantes, L.,Garrett, S.W.,Shipton, M.L.,Brearley, C.A.,Potter, B.V.L.,Gonzalez, B. Substrate promiscuity of inositol 1,4,5-trisphosphate kinase driven by structurally-modified ligands and active site plasticity. Nat Commun, 15:1502-1502, 2024 Cited by PubMed: 38374076DOI: 10.1038/s41467-024-45917-5 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.59 Å) |
Structure validation
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