8PPE
Human inositol 1,4,5-trisphosphate 3-kinase A (IP3K) catalytic domain in complex with DL-6-deoxy-6-phosphoryloxymethyl-scyllo-inositol 1,2,4-trisphosphate/ADP/Mn
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B | Inositol-trisphosphate 3-kinase A | polymer | 279 | 31877.3 | 2 | UniProt (P23677) Pfam (PF03770) In PDB | Homo sapiens (human) | Inositol 1,4,5-trisphosphate 3-kinase A,IP3 3-kinase A,IP3K A,InsP 3-kinase A |
| 2 | A, B | ADENOSINE-5'-DIPHOSPHATE | non-polymer | 427.2 | 2 | Chemie (ADP) | |||
| 3 | A, B | DL-6-deoxy-6-phosphoryloxymethyl-scyllo-inositol 1,2,4-trisphosphate | non-polymer | 514.1 | 2 | Chemie (7I8) | |||
| 4 | A | GLYCEROL | non-polymer | 92.1 | 1 | Chemie (GOL) | |||
| 5 | A, B | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | |||
| 6 | water | water | 18.0 | 388 | Chemie (HOH) |
Sequence modifications
A, B: 188 - 461 (UniProt: P23677)
| PDB | External Database | Details |
|---|---|---|
| Gly 183 | - | expression tag |
| Ser 184 | - | expression tag |
| His 185 | - | expression tag |
| Met 186 | - | expression tag |
| Ser 187 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 63754.5 | |
| Non-Polymers* | Number of molecules | 7 |
| Total formula weight | 2084.6 | |
| All* | Total formula weight | 65839.1 |
