8POL

Crystal structure of Plasmodium falciparum Sub1 protease

Summary for 8POL

Entry DOI	10.2210/pdb8pol/pdb
Descriptor	Subtilisin-like protease 1, CALCIUM ION, PHOSPHATE ION (3 entities in total)
Functional Keywords	protease, plasmodium falciparum, merozoite egress, ph-dependent dimerization, hydrolase
Biological source	Plasmodium falciparum (malaria parasite P. falciparum)
Total number of polymer chains	2
Total formula weight	156292.46
Authors	Martinez, M.,Bouillon, A.,Haouz, A.,Barale, J.C.,Alzari, P.M. (deposition date: 2023-07-05, release date: 2024-03-06, Last modification date: 2024-03-27)
Primary citation	Martinez, M.,Bouillon, A.,Brule, S.,Raynal, B.,Haouz, A.,Alzari, P.M.,Barale, J.-.C. Prodomain-driven enzyme dimerization: a pH-dependent autoinhibition mechanism that controls Plasmodium Sub1 activity before merozoite egress. Mbio, 15:e0019824-e0019824, 2024 Cited by PubMed: 38386597 DOI: 10.1128/mbio.00198-24 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.09 Å)

Structure validation