8POL
Crystal structure of Plasmodium falciparum Sub1 protease
Functional Information from PROSITE/UniProt
| site_id | PS00136 |
| Number of Residues | 12 |
| Details | SUBTILASE_ASP Serine proteases, subtilase family, aspartic acid active site. ICVIDSGIdynH |
| Chain | Residue | Details |
| A | ILE368-HIS379 |
| site_id | PS00137 |
| Number of Residues | 11 |
| Details | SUBTILASE_HIS Serine proteases, subtilase family, histidine active site. HGThVSGiISA |
| Chain | Residue | Details |
| A | HIS428-ALA438 |
| site_id | PS00138 |
| Number of Residues | 11 |
| Details | SUBTILASE_SER Serine proteases, subtilase family, serine active site. GTSmAaPhVAA |
| Chain | Residue | Details |
| A | GLY604-ALA614 |
Functional Information from SwissProt/UniProt
| site_id | SWS_FT_FI1 |
| Number of Residues | 6 |
| Details | ACT_SITE: Charge relay system => ECO:0000255|PROSITE-ProRule:PRU01240 |
| Chain | Residue | Details |
| A | ASP372 | |
| A | HIS428 | |
| A | SER606 | |
| B | ASP372 | |
| B | HIS428 | |
| B | SER606 |
| site_id | SWS_FT_FI2 |
| Number of Residues | 32 |
| Details | BINDING: BINDING => ECO:0000250|UniProtKB:O61142 |
| Chain | Residue | Details |
| A | GLU338 | |
| A | ILE406 | |
| A | ASP408 | |
| A | ASP409 | |
| A | ILE439 | |
| A | ASN442 | |
| A | ILE444 | |
| A | VAL446 | |
| B | GLU338 | |
| B | ASP381 | |
| B | GLU392 | |
| A | ASP381 | |
| B | ARG396 | |
| B | PHE399 | |
| B | ASP400 | |
| B | ASP401 | |
| B | ASP402 | |
| B | ASN404 | |
| B | ILE406 | |
| B | ASP408 | |
| B | ASP409 | |
| B | ILE439 | |
| A | GLU392 | |
| B | ASN442 | |
| B | ILE444 | |
| B | VAL446 | |
| A | ARG396 | |
| A | PHE399 | |
| A | ASP400 | |
| A | ASP401 | |
| A | ASP402 | |
| A | ASN404 |
| site_id | SWS_FT_FI3 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by autolysis => ECO:0000250|UniProtKB:O61142 |
| Chain | Residue | Details |
| A | ASP217 | |
| B | ASP217 |
| site_id | SWS_FT_FI4 |
| Number of Residues | 2 |
| Details | SITE: Cleavage; by PMX => ECO:0000269|PubMed:32109369 |
| Chain | Residue | Details |
| A | MET243 | |
| B | MET243 |
| site_id | SWS_FT_FI5 |
| Number of Residues | 2 |
| Details | SITE: Cleavage => ECO:0000250|UniProtKB:O61142 |
| Chain | Residue | Details |
| A | ASP249 | |
| B | ASP249 |
| site_id | SWS_FT_FI6 |
| Number of Residues | 22 |
| Details | CARBOHYD: N-linked (GlcNAc...) asparagine => ECO:0000255|PROSITE-ProRule:PRU00498 |
| Chain | Residue | Details |
| A | ASN112 | |
| A | ASN603 | |
| A | ASN675 | |
| B | ASN112 | |
| B | ASN171 | |
| B | ASN261 | |
| B | ASN317 | |
| B | ASN322 | |
| B | ASN417 | |
| B | ASN488 | |
| B | ASN501 | |
| A | ASN171 | |
| B | ASN520 | |
| B | ASN603 | |
| B | ASN675 | |
| A | ASN261 | |
| A | ASN317 | |
| A | ASN322 | |
| A | ASN417 | |
| A | ASN488 | |
| A | ASN501 | |
| A | ASN520 |
