8PFI

Crystal structure of human TLR8 in complex with compound 34

8PFI の概要

• エントリーDOI: 10.2210/pdb8pfi/pdb
• 分子名称: Toll-like receptor 8, alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: tlr8, toll-like receptor, immune, immune system
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 193151.76

構造登録者

Faller, M.,Zink, F. (登録日: 2023-06-16, 公開日: 2023-08-16, 最終更新日: 2023-08-30)

• 主引用文献: Alper, P.,Betschart, C.,Andre, C.,Boulay, T.,Cheng, D.,Deane, J.,Faller, M.,Feifel, R.,Glatthar, R.,Han, D.,Hemmig, R.,Jiang, T.,Knoepfel, T.,Maginnis, J.,Mutnick, D.,Pei, W.,Ruzzante, G.,Syka, P.,Zhang, G.,Zhang, Y.,Zink, F.,Zipfel, G.,Hawtin, S.,Junt, T.,Michellys, P.Y.; Discovery of the TLR7/8 Antagonist MHV370 for Treatment of Systemic Autoimmune Diseases.; Acs Med.Chem.Lett., 14:1054-1062, 2023; PubMed: 37583811; DOI: 10.1021/acsmedchemlett.3c00136

実験手法

X-RAY DIFFRACTION (2.785 Å)