8PET

Cryo-EM structure of the full-length human alpha1beta3 GABA(A) receptor (babba arrangement) in complex with nanobody Nb25, expressed with a 5-fold excess of beta3 over alpha1

8PET の概要

• エントリーDOI: 10.2210/pdb8pet/pdb
• EMDBエントリー: 17636
• 分子名称: Gamma-aminobutyric acid receptor subunit alpha-1, Gamma-aminobutyric acid receptor subunit beta-3, Nanobody Nb25, ... (10 entities in total)
• 機能のキーワード: neurotransmitter receptor, pentameric ligand-gated ion channel, type-a gaba receptor, gaba-a receptor, membrane protein
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 300537.53

構造登録者

Sente, A.,Malinauskas, T.,Naydenova, K.,Hardwick, S.W.,Chirgadze, D.Y.,Aricescu, A.R. (登録日: 2023-06-14, 公開日: 2025-07-02)

• 主引用文献: Sente, A.,Malinauskas, T.,Naydenova, K.,Hardwick, S.W.,Chirgadze, D.Y.,Aricescu, A.R.; Subunit abundance shapes GABAA receptor stoichiometry; To Be Published,

実験手法

ELECTRON MICROSCOPY (2.6 Å)