8PEB
OXA-48_Q5. Epistasis Arises from Shifting the Rate-Limiting Step during Enzyme Evolution
Summary for 8PEB
Entry DOI | 10.2210/pdb8peb/pdb |
Descriptor | Beta-lactamase, CHLORIDE ION, SULFATE ION, ... (6 entities in total) |
Functional Keywords | protein evolution. antibiotic resistance. oxa-48., hydrolase |
Biological source | Klebsiella pneumoniae |
Total number of polymer chains | 1 |
Total formula weight | 28413.30 |
Authors | Leiros, H.-K.S.,Frohlich, C. (deposition date: 2023-06-13, release date: 2024-02-14, Last modification date: 2024-06-12) |
Primary citation | Frohlich, C.,Bunzel, H.A.,Buda, K.,Mulholland, A.J.,van der Kamp, M.W.,Johnsen, P.J.,Leiros, H.S.,Tokuriki, N. Epistasis arises from shifting the rate-limiting step during enzyme evolution of a beta-lactamase. Nat Catal, 7:499-509, 2024 Cited by PubMed: 38828429DOI: 10.1038/s41929-024-01117-4 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.17 Å) |
Structure validation
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