8PEB
OXA-48_Q5. Epistasis Arises from Shifting the Rate-Limiting Step during Enzyme Evolution
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Beta-lactamase | polymer | 242 | 28002.7 | 1 | UniProt (Q6XEC0) Pfam (PF00905) In PDB | Klebsiella pneumoniae | |
| 2 | A | CHLORIDE ION | non-polymer | 35.5 | 3 | Chemie (CL) | |||
| 3 | A | SULFATE ION | non-polymer | 96.1 | 1 | Chemie (SO4) | |||
| 4 | A | DI(HYDROXYETHYL)ETHER | non-polymer | 106.1 | 1 | Chemie (PEG) | |||
| 5 | A | MALONATE ION | non-polymer | 102.0 | 1 | Chemie (MLI) | |||
| 6 | water | water | 18.0 | 352 | Chemie (HOH) |
Sequence modifications
A: 24 - 265 (UniProt: Q6XEC0)
| PDB | External Database | Details |
|---|---|---|
| Val 33 | Ala 33 | engineered mutation |
| Glu 51 | Lys 51 | engineered mutation |
| Leu 72 | Phe 72 | engineered mutation |
| Ala 212 | Ser 212 | engineered mutation |
| Ala 213 | Thr 213 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 28002.7 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 410.6 | |
| All* | Total formula weight | 28413.3 |
