8PD4

Crystal structure of TRIM58 PRY-SPRY domain

Summary for 8PD4

Entry DOI	10.2210/pdb8pd4/pdb
Descriptor	E3 ubiquitin-protein ligase TRIM58 (2 entities in total)
Functional Keywords	e3 ligase, trim58, pry-spry, transferase
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	48469.13
Authors	Renatus, M.,Schroeder, M. (deposition date: 2023-06-11, release date: 2024-01-31, Last modification date: 2024-02-07)
Primary citation	Hoegenauer, K.,An, S.,Axford, J.,Benander, C.,Bergsdorf, C.,Botsch, J.,Chau, S.,Fernandez, C.,Gleim, S.,Hassiepen, U.,Hunziker, J.,Joly, E.,Keller, A.,Lopez Romero, S.,Maher, R.,Mangold, A.S.,Mickanin, C.,Mihalic, M.,Neuner, P.,Patterson, A.W.,Perruccio, F.,Roggo, S.,Scesa, J.,Schroder, M.,Shkoza, D.,Thai, B.,Vulpetti, A.,Renatus, M.,Reece-Hoyes, J.S. Discovery of Ligands for TRIM58, a Novel Tissue-Selective E3 Ligase. Acs Med.Chem.Lett., 14:1631-1639, 2023 Cited by PubMed: 38116426 DOI: 10.1021/acsmedchemlett.3c00259 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.714 Å)

Structure validation