8PAU

Crystal structure of MAP4K1 with a SMOL inhibitor

Summary for 8PAU

• Entry DOI: 10.2210/pdb8pau/pdb
• Descriptor: Mitogen-activated protein kinase kinase kinase kinase 1, [(5~{R})-2-[[3,5-bis(fluoranyl)-4-[[3-(trifluoromethyl)-1~{H}-pyrrolo[2,3-b]pyridin-4-yl]oxy]phenyl]amino]-5-fluoranyl-4,6-dihydro-1,3-oxazin-5-yl]methanol (3 entities in total)
• Functional Keywords: kinase, inhibitor, drug discovery, transferase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 2
• Total formula weight: 65531.89

Authors

Friberg, A. (deposition date: 2023-06-08, release date: 2024-06-26)

• Primary citation: Mowat, J.,Offringa, R.; Identification and optimization of Azaindole based MAP4K1 Inhibitors and the discovery of BAY-405; To Be Published,

Experimental method