8P88

X-ray structure of cardiotoxic light chain H3 in complex to neutralizing nanobody C4

Summary for 8P88

• Entry DOI: 10.2210/pdb8p88/pdb
• Descriptor: Light Chain H3, Nanobody C4, CHLORIDE ION, ... (5 entities in total)
• Functional Keywords: al amyloidosis, toxicity, neutralization, nanobody, immune system
• Biological source: Homo sapiens; More
• Total number of polymer chains: 2
• Total formula weight: 35785.79

Authors

Broggini, L.,Ricagno, S. (deposition date: 2023-05-31, release date: 2024-01-31, Last modification date: 2024-02-07)

• Primary citation: Broggini, L.,Barzago, M.M.,Speranzini, V.,Schulte, T.,Sonzini, F.,Giono, M.,Romeo, M.,Milani, P.,Caminito, S.,Mazzini, G.,Rognoni, P.,Merlini, G.,Pappone, C.,Anastasia, L.,Nuvolone, M.,Palladini, G.,Diomede, L.,Ricagno, S.; Nanobodies counteract the toxicity of an amyloidogenic light chain by stabilizing a partially open dimeric conformation.; J.Mol.Biol., 435:168320-168320, 2023; PubMed: 37865287; DOI: 10.1016/j.jmb.2023.168320

Experimental method

X-RAY DIFFRACTION (2.022 Å)