8P4Z
Crystal structure of the human CDK7 kinase domain in complex with LDC4297
Summary for 8P4Z
Entry DOI | 10.2210/pdb8p4z/pdb |
Descriptor | Cyclin-dependent kinase 7, 2-[(3R)-piperidin-3-yl]oxy-8-propan-2-yl-N-[(2-pyrazol-1-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine, GLYCEROL, ... (6 entities in total) |
Functional Keywords | transferase, cyclin-dependent kinase, cell division, cell cycle |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 70737.70 |
Authors | Laursen, M.,Caing-Carlsson, R.,Houssari, R.,Javadi, A.,Kimbung, Y.R.,Murina, V.,Orozco-Rodriguez, J.M.,Svensson, A.,Welin, M.,Logan, D.,Svensson, B.,Walse, B. (deposition date: 2023-05-23, release date: 2023-06-14, Last modification date: 2024-02-07) |
Primary citation | Laursen, M.,Caing-Carlsson, R.,Houssari, R.,Javadi, A.,Kimbung, Y.R.,Murina, V.,Orozco-Rodriguez, J.M.,Svensson, A.,Welin, M.,Logan, D.,Svensson, B.,Walse, B. Crystal structure of the human CDK7 kinase domain in complex with LDC4297 To Be Published, |
Experimental method | X-RAY DIFFRACTION (2.75 Å) |
Structure validation
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