8P3J

Fusion hSlp2-a_Rab27A non-covalent complex with hit fragment IMP-1704

Summary for 8P3J

• Entry DOI: 10.2210/pdb8p3j/pdb
• Descriptor: Synaptotagmin-like protein 2,Ras-related protein Rab-27A, ~{N}-(4-pyrrolidin-1-ylsulfonylphenyl)prop-2-enamide, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, ... (6 entities in total)
• Functional Keywords: small gtpase, targeted covalent inhibitors, high throughput screening, drug discovery, vesicle trafficking, breast cancer, cytosolic protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 2
• Total formula weight: 54254.95

Authors

De Vita, E.,Brustur, D.,Tersa, M.,Petracca, R.,Morgan, R.M.L.,Lanyon-Hogg, T.,Norman, J.C.,Cota, E.,Tate, E.W. (deposition date: 2023-05-17, release date: 2024-11-20)

• Primary citation: De Vita, E.,Brustur, D.,Tersa, M.,Petracca, R.,Morgan, R.M.L.,Lanyon-Hogg, T.,Norman, J.C.,Cota, E.,Tate, E.W.; Targeted covalent inhibitors of the small GTPase Rab27A; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.16 Å)