8P0M
Crystal structure of TEAD3 in complex with IAG933
Summary for 8P0M
Entry DOI | 10.2210/pdb8p0m/pdb |
Descriptor | Transcriptional enhancer factor TEF-5, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, MYRISTIC ACID, ... (7 entities in total) |
Functional Keywords | inhibitor, complex, transcription |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 105243.84 |
Authors | Scheufler, C.,Villard, F.,Chau, S. (deposition date: 2023-05-10, release date: 2024-04-10, Last modification date: 2024-08-07) |
Primary citation | Chapeau, E.A.,Sansregret, L.,Galli, G.G.,Chene, P.,Wartmann, M.,Mourikis, T.P.,Jaaks, P.,Baltschukat, S.,Barbosa, I.A.M.,Bauer, D.,Brachmann, S.M.,Delaunay, C.,Estadieu, C.,Faris, J.E.,Furet, P.,Harlfinger, S.,Hueber, A.,Jimenez Nunez, E.,Kodack, D.P.,Mandon, E.,Martin, T.,Mesrouze, Y.,Romanet, V.,Scheufler, C.,Sellner, H.,Stamm, C.,Sterker, D.,Tordella, L.,Hofmann, F.,Soldermann, N.,Schmelzle, T. Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers. Nat Cancer, 5:1102-1120, 2024 Cited by PubMed: 38565920DOI: 10.1038/s43018-024-00754-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.961 Å) |
Structure validation
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