8P0M

Crystal structure of TEAD3 in complex with IAG933

8P0M の概要

• エントリーDOI: 10.2210/pdb8p0m/pdb
• 分子名称: Transcriptional enhancer factor TEF-5, 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, MYRISTIC ACID, ... (7 entities in total)
• 機能のキーワード: inhibitor, complex, transcription
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 105243.84

構造登録者

Scheufler, C.,Villard, F.,Chau, S. (登録日: 2023-05-10, 公開日: 2024-04-10, 最終更新日: 2024-08-07)

• 主引用文献: Chapeau, E.A.,Sansregret, L.,Galli, G.G.,Chene, P.,Wartmann, M.,Mourikis, T.P.,Jaaks, P.,Baltschukat, S.,Barbosa, I.A.M.,Bauer, D.,Brachmann, S.M.,Delaunay, C.,Estadieu, C.,Faris, J.E.,Furet, P.,Harlfinger, S.,Hueber, A.,Jimenez Nunez, E.,Kodack, D.P.,Mandon, E.,Martin, T.,Mesrouze, Y.,Romanet, V.,Scheufler, C.,Sellner, H.,Stamm, C.,Sterker, D.,Tordella, L.,Hofmann, F.,Soldermann, N.,Schmelzle, T.; Direct and selective pharmacological disruption of the YAP-TEAD interface by IAG933 inhibits Hippo-dependent and RAS-MAPK-altered cancers.; Nat Cancer, 5:1102-1120, 2024; PubMed: 38565920; DOI: 10.1038/s43018-024-00754-9

実験手法

X-RAY DIFFRACTION (1.961 Å)