8OZ2

Human Aldose Reductase Mutant A299G/L300A in Complex with a Ligand with an IDD Structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid)

Summary for 8OZ2

• Entry DOI: 10.2210/pdb8oz2/pdb
• Descriptor: Aldo-keto reductase family 1 member B1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, {5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid, ... (5 entities in total)
• Functional Keywords: human aldose reductase, har, aldo-keto-reductase, ligand, idd06, nadp+, diabetes, mutant a299g/l300a, open transient pocket, oxidoreductase
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 1
• Total formula weight: 37126.05

Authors

Klee, L.-S.,Heine, A.,Klebe, G. (deposition date: 2023-05-08, release date: 2024-05-15)

• Primary citation: Klee, L.-S.,Heine, A.,Klebe, G.,Scheer, F.; Human Aldose Reductase Mutant A299G/L300A in Complex with a Ligand with an IDD Structure ({5-fluoro-2-[(3-nitrobenzyl)carbamoyl]phenoxy}acetic acid); To Be Published,

Experimental method

X-RAY DIFFRACTION (1.04 Å)