8OXU
Crystal Structure of the Hsp90-LA1011 Complex
Summary for 8OXU
Entry DOI | 10.2210/pdb8oxu/pdb |
Descriptor | ATP-dependent molecular chaperone HSP82, dimethyl 2,6-bis[2-(dimethylamino)ethyl]-1-methyl-4-[4-(trifluoromethyl)phenyl]-4~{H}-pyridine-3,5-dicarboxylate (3 entities in total) |
Functional Keywords | inhibitor complex, chaperone |
Biological source | Saccharomyces cerevisiae (baker's yeast) |
Total number of polymer chains | 4 |
Total formula weight | 110250.86 |
Authors | Roe, S.M.,Prodromou, C. (deposition date: 2023-05-02, release date: 2023-07-12, Last modification date: 2024-06-19) |
Primary citation | Roe, S.M.,Torok, Z.,McGown, A.,Horvath, I.,Spencer, J.,Pazmany, T.,Vigh, L.,Prodromou, C. The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by Which LA1011 May Improve the Prognosis of Alzheimer's Disease. Biomolecules, 13:-, 2023 Cited by PubMed: 37509087DOI: 10.3390/biom13071051 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.94 Å) |
Structure validation
Download full validation report