8OXU

Crystal Structure of the Hsp90-LA1011 Complex

8OXU の概要

• エントリーDOI: 10.2210/pdb8oxu/pdb
• 分子名称: ATP-dependent molecular chaperone HSP82, dimethyl 2,6-bis[2-(dimethylamino)ethyl]-1-methyl-4-[4-(trifluoromethyl)phenyl]-4~{H}-pyridine-3,5-dicarboxylate (3 entities in total)
• 機能のキーワード: inhibitor complex, chaperone
• 由来する生物種: Saccharomyces cerevisiae (baker's yeast)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 110250.86

構造登録者

Roe, S.M.,Prodromou, C. (登録日: 2023-05-02, 公開日: 2023-07-12, 最終更新日: 2024-06-19)

• 主引用文献: Roe, S.M.,Torok, Z.,McGown, A.,Horvath, I.,Spencer, J.,Pazmany, T.,Vigh, L.,Prodromou, C.; The Crystal Structure of the Hsp90-LA1011 Complex and the Mechanism by Which LA1011 May Improve the Prognosis of Alzheimer's Disease.; Biomolecules, 13:-, 2023; PubMed: 37509087; DOI: 10.3390/biom13071051

実験手法

X-RAY DIFFRACTION (2.94 Å)