8OMV
Crystal structure of the constitutively active S117E/S181E mutant of human IKK2
Summary for 8OMV
Entry DOI | 10.2210/pdb8omv/pdb |
Descriptor | Inhibitor of nuclear factor kappa-B kinase subunit beta (1 entity in total) |
Functional Keywords | ikk, nf-kappab, ikba, docking, transferase |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 5 |
Total formula weight | 387043.91 |
Authors | McEwen, A.G.,Li, C.,Moro, S.,Poussin-Courmontagne, P.,Zanier, K. (deposition date: 2023-03-31, release date: 2024-04-10) |
Primary citation | Li, C.,Moro, S.,Shastak, K.,O'Reily, F.,Donzeau, M.,Graziadei, A.,McEwen, A.G.,Poussin-Courmontagne, P.,Bachelart, T.,Fiskin, M.,Berrodier, N.,Orfanoudakis, G.,Poterszman, A.,Torbeev, V.,Rappsilber, J.,Davy, N.,Chariot, A.,Zanier, K. A novel YDD(phi)X(phi) linear motif mediates docking of IKK catalytic dimers to NF-kappaB substrates: structural and functional insights To be published, |
Experimental method | X-RAY DIFFRACTION (4.16 Å) |
Structure validation
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