8OKU
Salt-Inducible Kinase 3 in complex with an inhibitor
Summary for 8OKU
Entry DOI | 10.2210/pdb8oku/pdb |
Descriptor | Serine/threonine-protein kinase SIK3, ~{N}-ethyl-4-[5-[1-(2-hydroxyethyl)pyrazol-4-yl]benzimidazol-1-yl]-2,6-dimethoxy-benzamide (3 entities in total) |
Functional Keywords | kinase uba inhibitor, signaling protein |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 81671.01 |
Authors | Flower, T.G.,Leonard, P.M.,Lamers, M.B.A.C.,Mollat, P. (deposition date: 2023-03-29, release date: 2024-01-10, Last modification date: 2024-01-24) |
Primary citation | Temal-Laib, T.,Peixoto, C.,Desroy, N.,De Lemos, E.,Bonnaterre, F.,Bienvenu, N.,Picolet, O.,Sartori, E.,Bucher, D.,Lopez-Ramos, M.,Roca Magadan, C.,Laenen, W.,Flower, T.,Mollat, P.,Bugaud, O.,Touitou, R.,Pereira Fernandes, A.,Lavazais, S.,Monjardet, A.,Borgonovi, M.,Gosmini, R.,Brys, R.,Amantini, D.,De Vos, S.,Andrews, M. Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312. J.Med.Chem., 67:380-401, 2024 Cited by PubMed: 38147525DOI: 10.1021/acs.jmedchem.3c01428 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (3.1 Å) |
Structure validation
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