8OKU
Salt-Inducible Kinase 3 in complex with an inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Serine/threonine-protein kinase SIK3 | polymer | 348 | 40400.0 | 2 | UniProt (Q9Y2K2) Pfam (PF00069) Pfam (PF23312) | Homo sapiens (human) | Salt-inducible kinase 3,SIK-3,Serine/threonine-protein kinase QSK |
| 2 | C, D (A, B) | ~{N}-ethyl-4-[5-[1-(2-hydroxyethyl)pyrazol-4-yl]benzimidazol-1-yl]-2,6-dimethoxy-benzamide | non-polymer | 435.5 | 2 | Chemie (VRU) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A, B: 60 - 394 (UniProt: Q9Y2K2)
| PDB | External Database | Details |
|---|---|---|
| Met 47 | - | initiating methionine |
| His 48 | - | expression tag |
| His 49 | - | expression tag |
| His 50 | - | expression tag |
| His 51 | - | expression tag |
| His 52 | - | expression tag |
| His 53 | - | expression tag |
| Leu 54 | - | expression tag |
| Val 55 | - | expression tag |
| Pro 56 | - | expression tag |
| Arg 57 | - | expression tag |
| Gly 58 | - | expression tag |
| Ser 59 | - | expression tag |
| Asp 221 | Thr 221 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 80800.1 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 871.0 | |
| All* | Total formula weight | 81671.0 |
