8OKU

Salt-Inducible Kinase 3 in complex with an inhibitor

Summary for 8OKU

Entry DOI	10.2210/pdb8oku/pdb
Descriptor	Serine/threonine-protein kinase SIK3, ~{N}-ethyl-4-[5-[1-(2-hydroxyethyl)pyrazol-4-yl]benzimidazol-1-yl]-2,6-dimethoxy-benzamide (3 entities in total)
Functional Keywords	kinase uba inhibitor, signaling protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	81671.01
Authors	Flower, T.G.,Leonard, P.M.,Lamers, M.B.A.C.,Mollat, P. (deposition date: 2023-03-29, release date: 2024-01-10, Last modification date: 2024-01-24)
Primary citation	Temal-Laib, T.,Peixoto, C.,Desroy, N.,De Lemos, E.,Bonnaterre, F.,Bienvenu, N.,Picolet, O.,Sartori, E.,Bucher, D.,Lopez-Ramos, M.,Roca Magadan, C.,Laenen, W.,Flower, T.,Mollat, P.,Bugaud, O.,Touitou, R.,Pereira Fernandes, A.,Lavazais, S.,Monjardet, A.,Borgonovi, M.,Gosmini, R.,Brys, R.,Amantini, D.,De Vos, S.,Andrews, M. Optimization of Selectivity and Pharmacokinetic Properties of Salt-Inducible Kinase Inhibitors that Led to the Discovery of Pan-SIK Inhibitor GLPG3312. J.Med.Chem., 67:380-401, 2024 Cited by PubMed: 38147525 DOI: 10.1021/acs.jmedchem.3c01428 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation