8OH2

Structure of the Tau-PAM4 Type 1 amyloid fibril

Summary for 8OH2

Entry DOI	10.2210/pdb8oh2/pdb
EMDB information	16876
Descriptor	Microtubule-associated protein tau (2 entities in total)
Functional Keywords	amyloid, tau, helical, cross-beta, fibril, neurodegeneration, protein fibril
Biological source	synthetic construct
Total number of polymer chains	36
Total formula weight	51754.39
Authors	Wilkinson, M.,Louros, N.,Tsaka, G.,Ramakers, M.,Morelli, C.,Garcia, T.,Gallardo, R.U.,D'Haeyer, S.,Goossens, V.,Audenaert, D.,Thal, D.R.,Ranson, N.A.,Radford, S.E.,Rousseau, F.,Schymkowitz, J. (deposition date: 2023-03-20, release date: 2024-02-21)
Primary citation	Louros, N.,Wilkinson, M.,Tsaka, G.,Ramakers, M.,Morelli, C.,Garcia, T.,Gallardo, R.,D'Haeyer, S.,Goossens, V.,Audenaert, D.,Thal, D.R.,Mackenzie, I.R.,Rademakers, R.,Ranson, N.A.,Radford, S.E.,Rousseau, F.,Schymkowitz, J. Local structural preferences in shaping tau amyloid polymorphism. Nat Commun, 15:1028-1028, 2024 Cited by PubMed: 38310108 DOI: 10.1038/s41467-024-45429-2 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.6 Å)

Structure validation