8OGH

Truncated 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis with butylacetylphosphonate (BAP) bound

Summary for 8OGH

Entry DOI	10.2210/pdb8ogh/pdb
Descriptor	1-deoxy-D-xylulose-5-phosphate synthase, [(S)-1-[3-[(4-azanyl-2-methyl-pyrimidin-5-yl)methyl]-4-methyl-5-[2-[oxidanyl(phosphonooxy)phosphoryl]oxyethyl]-1,3-thiazol-3-ium-2-yl]-1-oxidanyl-ethyl]-butoxy-phosphinic acid, GLYCEROL, ... (7 entities in total)
Functional Keywords	complex, inhibitor, thdp, mep-pathway, transferase
Biological source	Mycobacterium tuberculosis H37Rv More
Total number of polymer chains	2
Total formula weight	129448.61
Authors	Gawriljuk, O.V.,Oerlemans, R.,Groves, R.M. (deposition date: 2023-03-20, release date: 2023-05-10, Last modification date: 2023-10-25)
Primary citation	Gawriljuk, V.O.,Oerlemans, R.,Gierse, R.M.,Jotwani, R.,Hirsch, A.K.H.,Groves, M.R. Structure of Mycobacterium tuberculosis 1-Deoxy-D-Xylulose 5-Phosphate Synthase in Complex with Butylacetylphosphonate Crystals, 13:-, 2023 Cited by DOI: 10.3390/cryst13050737 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.6 Å)

Structure validation