8KHF

Structure of the human ATP synthase bound to bedaquiline (membrane domain)

Summary for 8KHF

• Entry DOI: 10.2210/pdb8khf/pdb
• EMDB information: 37243
• Descriptor: ATP synthase F(0) complex subunit C1, mitochondrial, ATP synthase subunit f, mitochondrial, ATP synthase subunit g, mitochondrial, ... (13 entities in total)
• Functional Keywords: atp synthase, human, cryo-em, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 19
• Total formula weight: 225081.97

Authors

Lai, Y.,Zhang, Y. (deposition date: 2023-08-21, release date: 2024-05-01, Last modification date: 2024-08-21)

• Primary citation: Zhang, Y.,Lai, Y.,Zhou, S.,Ran, T.,Zhang, Y.,Zhao, Z.,Feng, Z.,Yu, L.,Xu, J.,Shi, K.,Wang, J.,Pang, Y.,Li, L.,Chen, H.,Guddat, L.W.,Gao, Y.,Liu, F.,Rao, Z.,Gong, H.; Inhibition of M. tuberculosis and human ATP synthase by BDQ and TBAJ-587.; Nature, 631:409-414, 2024; PubMed: 38961288; DOI: 10.1038/s41586-024-07605-8

Experimental method

ELECTRON MICROSCOPY (3.13 Å)