8K18

Neutralization antibody ZCP4C9 bound with SARS-CoV-2 Omicron BA.5 RBD

Summary for 8K18

• Entry DOI: 10.2210/pdb8k18/pdb
• EMDB information: 36788
• Descriptor: Spike protein S1, ZCP4C9 heavy chain, ZCP4C9 light chain (3 entities in total)
• Functional Keywords: viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2; More
• Total number of polymer chains: 3
• Total formula weight: 46576.08

Authors

Tang, B.,Dang, S. (deposition date: 2023-07-10, release date: 2024-10-09, Last modification date: 2025-10-22)

Primary citation

Luo, M.,Zhou, R.,Tang, B.,Liu, H.,Chen, B.,Liu, N.,Mo, Y.,Zhang, P.,Lee, Y.L.,Ip, J.D.,Wing-Ho Chu, A.,Chan, W.M.,Man, H.O.,Chen, Y.,To, K.K.,Yuen, K.Y.,Dang, S.,Chen, Z.
Ultrapotent class I neutralizing antibodies post Omicron breakthrough infection overcome broad SARS-CoV-2 escape variants.
Ebiomedicine, 108:105354-105354, 2024

PubMed Abstract: The spread of emerging SARS-CoV-2 immune escape sublineages, especially JN.1 and KP.2, has resulted in new waves of COVID-19 globally. The evolving memory B cell responses elicited by the parental Omicron variants to subvariants with substantial antigenic drift remain incompletely investigated.

PubMed: 39341153
DOI: 10.1016/j.ebiom.2024.105354

Experimental method

ELECTRON MICROSCOPY (3.68 Å)