8JYR
Crystal structure of anti-HER2 antibody H2Mab-119 in complex with HER2 domain I
Summary for 8JYR
Entry DOI | 10.2210/pdb8jyr/pdb |
Descriptor | Receptor tyrosine-protein kinase erbB-2, H2Mab-119 VH-CH1, H2Mab-119 light chain, ... (5 entities in total) |
Functional Keywords | her2, antibody, immune system |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 3 |
Total formula weight | 70769.13 |
Authors | Arimori, T.,Takagi, J. (deposition date: 2023-07-03, release date: 2024-03-13, Last modification date: 2024-10-16) |
Primary citation | Arimori, T.,Mihara, E.,Suzuki, H.,Ohishi, T.,Tanaka, T.,Kaneko, M.K.,Takagi, J.,Kato, Y. Locally misfolded HER2 expressed on cancer cells is a promising target for development of cancer-specific antibodies. Structure, 32:536-549.e5, 2024 Cited by PubMed: 38460519DOI: 10.1016/j.str.2024.02.007 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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