8JYG
Crystal structure of Human HPSE1 in complex with inhibitor
Summary for 8JYG
Entry DOI | 10.2210/pdb8jyg/pdb |
Descriptor | Heparanase 50 kDa subunit, Heparanase, (5~{S},6~{R},7~{S},8~{S})-6,7,8-tris(oxidanyl)-2-[2-(3-phenoxyphenyl)ethyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid, ... (6 entities in total) |
Functional Keywords | endo-glucoronidase, heparanase-1, hep, hpa, hpa1, hpr1, hpse1, hse1, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 54098.08 |
Authors | |
Primary citation | Imai, Y.,Suzuki, R.,Wakasugi, D.,Matsuda, D.,Tanaka-Yamamoto, N.,Ohki, Y.,Mima, M.,Endo, M.,Tabata, R.,Matsuzawa, H.,Hasegawa, Y.,Kato, S.,Sugisaki, M.,Miyagawa, H.,Fujimoto, N.,Fukunaga, T.,Kato, S.,Takahashi, T.,Kakinuma, H. Structure-based lead optimization to improve potency and selectivity of a novel tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid series of heparanase-1 inhibitor. Bioorg.Med.Chem., 93:117460-117460, 2023 Cited by PubMed: 37660465DOI: 10.1016/j.bmc.2023.117460 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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