8JYG
Crystal structure of Human HPSE1 in complex with inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Heparanase 50 kDa subunit | polymer | 386 | 43464.1 | 1 | UniProt (Q9Y251) Pfam (PF03662) | Homo sapiens (human) | |
| 2 | B (B) | Heparanase | polymer | 76 | 8415.7 | 1 | UniProt (Q9Y251) | Homo sapiens (human) | Endo-glucoronidase,Heparanase-1,Hpa1 |
| 3 | C (A) | (5~{S},6~{R},7~{S},8~{S})-6,7,8-tris(oxidanyl)-2-[2-(3-phenoxyphenyl)ethyl]-5,6,7,8-tetrahydroimidazo[1,2-a]pyridine-5-carboxylic acid | non-polymer | 410.4 | 1 | Chemie (V8R) PubChem (168490204) | |||
| 4 | AA, D, E, F, G... (A) | 1,2-ETHANEDIOL | non-polymer | 62.1 | 22 | Chemie (EDO) | |||
| 5 | S, T (A) | 2-acetamido-2-deoxy-beta-D-glucopyranose | non-polymer | 221.2 | 2 | Chemie (NAG) | |||
| 6 | BA, CA (A, B) | water | water | 18.0 | 208 | Chemie (HOH) |
Sequence modifications
A: 158 - 543 (UniProt: Q9Y251)
B: 35 - 109 (UniProt: Q9Y251)
| PDB | External Database | Details |
|---|---|---|
| Arg 307 | Lys 307 | engineered mutation |
| PDB | External Database | Details |
|---|---|---|
| Ala 34 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 51879.7 | |
| Non-Polymers* | Number of molecules | 25 |
| Total formula weight | 2218.3 | |
| All* | Total formula weight | 54098.1 |
