8JNB
CRAF ras-binding domain chimera, ligand complex
Summary for 8JNB
Entry DOI | 10.2210/pdb8jnb/pdb |
Descriptor | RAF proto-oncogene serine/threonine-protein kinase, CRaf, 2-[4-[[(2S)-1-ethanoyl-3-oxidanylidene-2H-indol-2-yl]methyl]-2-methoxy-phenoxy]ethanamide (3 entities in total) |
Functional Keywords | raf, craf, chimera, beta-grasp, signaling protein |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 1 |
Total formula weight | 10885.41 |
Authors | |
Primary citation | Yoshikawa, Y.,Makino, Y.,Kubota, H.,Kawamura, T.,Matsumoto, S.,Yuki, H.,Shibaike, A.,Okamura, M.,Okada, T.,Kataoka, T.,Honma, T.,Kumasaka, T.,Koyama, H.,Shima, F. Small-molecule RAS/RAF-binding Inhibitors Allosterically Disrupt RAF Conformation and Exert Efficacy Against Broad-spectrum RAS-driven Cancers To Be Published, |
Experimental method | X-RAY DIFFRACTION (1.62 Å) |
Structure validation
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