8JH1

Crystal Structure of the Csm6 Y161A mutant from Thermus thermophilus HB8 in complex with cyclic-tetraadenylate (cA4)

Summary for 8JH1

• Entry DOI: 10.2210/pdb8jh1/pdb
• Descriptor: CRISPR system endoribonuclease Csm6, RNA (5'-R(P*AP*AP*AP*A)-3') (3 entities in total)
• Functional Keywords: thermus thermophilus hb8, csm6, endoribonuclease, cyclic-tetraadenylate (ca4), hydrolase
• Biological source: Thermus thermophilus HB8; More
• Total number of polymer chains: 3
• Total formula weight: 103199.19

Authors

Lin, Z.,Du, L. (deposition date: 2023-05-22, release date: 2023-12-13, Last modification date: 2024-01-31)

• Primary citation: Du, L.,Zhu, Q.,Lin, Z.; Molecular mechanism of allosteric activation of the CRISPR ribonuclease Csm6 by cyclic tetra-adenylate.; Embo J., 43:304-315, 2024; PubMed: 38177499; DOI: 10.1038/s44318-023-00017-w

Experimental method

X-RAY DIFFRACTION (2.89 Å)