8JEO

Crystal structure of TIGIT in complexed with Tiragolumab

8JEO の概要

• エントリーDOI: 10.2210/pdb8jeo/pdb
• 分子名称: T-cell immunoreceptor with Ig and ITIM domains, antibody heavy chain, antibody light chain, ... (4 entities in total)
• 機能のキーワード: immunotherapy, antibody, checkpoint inhibitor, immune system
• 由来する生物種: Homo sapiens (human); 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 124832.78

構造登録者

Sun, J.,Zhang, X.X.,Song, J. (登録日: 2023-05-16, 公開日: 2024-02-28, 最終更新日: 2024-05-22)

• 主引用文献: Sun, J.,Zhang, X.,Xue, L.,Cheng, L.,Zhang, J.,Chen, X.,Shen, Z.,Li, K.,Wang, L.,Huang, C.,Song, J.; Structural insights into the unique pH-responsive characteristics of the anti-TIGIT therapeutic antibody Ociperlimab.; Structure, 32:550-, 2024; PubMed: 38460520; DOI: 10.1016/j.str.2024.02.009

実験手法

X-RAY DIFFRACTION (2.06 Å)