8JE5

Crystal Structure of Anopheles culicifacies Prolyl-tRNA Synthetase (AcPRS) in complex with Halofuginone

Summary for 8JE5

• Entry DOI: 10.2210/pdb8je5/pdb
• Descriptor: PROLYL-TRNA SYNTHETASE, 7-bromo-6-chloro-3-{3-[(2R,3S)-3-hydroxypiperidin-2-yl]-2-oxopropyl}quinazolin-4(3H)-one, ZINC ION, ... (6 entities in total)
• Functional Keywords: malaria, vector, anopheles, mosquito, larvicidal, aminoacyl-trna synthetase, ligase, ligase-inhibitor complex, ligase/inhibitor
• Biological source: Anopheles culicifacies
• Total number of polymer chains: 2
• Total formula weight: 117544.83

Authors

Goswami, R.,Manickam, Y.,Chhibber-Goel, J.,Harlos, K.,Sharma, A. (deposition date: 2023-05-15, release date: 2024-11-27)

• Primary citation: Goswami, R.,Chhibber-Goel, J.,Manickam, Y.,Gupta, S.,Harlos, K.,Laleu, B.,Sharma, A.; Targeting Prolyl-tRNA synthetase of Anopheles culicifacies for the development of new larvicide; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.57 Å)