8J9W

Cryo-EM structure of the African swine fever virus topoisomerase 2 complexed with Cut02bDNA and etoposide (EDI-2)

Summary for 8J9W

• Entry DOI: 10.2210/pdb8j9w/pdb
• EMDB information: 36117
• Descriptor: DNA topoisomerase 2, DNA (5'-D(*AP*AP*GP*AP*AP*CP*TP*CP*TP*GP*TP*AP*G)-3'), DNA (5'-D(*CP*AP*TP*GP*CP*TP*AP*CP*AP*GP*AP*GP*TP*TP*CP*TP*T)-3'), ... (5 entities in total)
• Functional Keywords: topoisomerase, asfv, inhibitor, viral protein, isomerase-dna complex, isomerase/dna
• Biological source: African swine fever virus; More
• Total number of polymer chains: 6
• Total formula weight: 292424.89

Authors

Chang, C.-W.,Tsai, M.-D. (deposition date: 2023-05-05, release date: 2024-02-07, Last modification date: 2024-04-17)

• Primary citation: Chang, C.M.,Wang, S.C.,Wang, C.H.,Pang, A.H.,Yang, C.H.,Chang, Y.K.,Wu, W.J.,Tsai, M.D.; A unified view on enzyme catalysis by cryo-EM study of a DNA topoisomerase.; Commun Chem, 7:45-45, 2024; PubMed: 38418525; DOI: 10.1038/s42004-024-01129-y

Experimental method

ELECTRON MICROSCOPY (2.76 Å)