8J6K

Crystal structure of pro-interleukin-18 and caspase-4 complex

This is a non-PDB format compatible entry.

Summary for 8J6K

• Entry DOI: 10.2210/pdb8j6k/pdb
• Descriptor: Caspase-4 subunit p20, Caspase-4 subunit p10, Interleukin-18, ... (4 entities in total)
• Functional Keywords: inflammatory cytokine, enzyme, immune system, hydrolase-immune system complex, hydrolase/immune system
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 4
• Total formula weight: 70557.54

Authors

Sun, Q.,Hou, Y.J.,Ding, J. (deposition date: 2023-04-26, release date: 2023-11-29, Last modification date: 2023-12-27)

• Primary citation: Shi, X.,Sun, Q.,Hou, Y.,Zeng, H.,Cao, Y.,Dong, M.,Ding, J.,Shao, F.; Recognition and maturation of IL-18 by caspase-4 noncanonical inflammasome.; Nature, 624:442-450, 2023; PubMed: 37993714; DOI: 10.1038/s41586-023-06742-w

Experimental method

X-RAY DIFFRACTION (3.12 Å)