8IZC

Human CK1 Delta Kinase structure bound to Inhibitor

8IZC の概要

• エントリーDOI: 10.2210/pdb8izc/pdb
• 分子名称: Casein kinase I isoform delta, SULFATE ION, ~{N}5-~{tert}-butyl-2-(3-chloranyl-4-fluoranyl-phenyl)-6,7-dihydro-4~{H}-pyrazolo[1,5-a]pyrazine-3,5-dicarboxamide, ... (4 entities in total)
• 機能のキーワード: ck1, kinase, inhibitor, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 68882.14

構造登録者

Ghosh, K. (登録日: 2023-04-06, 公開日: 2024-04-10)

• 主引用文献: Velaparthi, U.,Selvakumar, K.; The Discovery of BMS-986164, a Potent, Selective and Orally Efficacious CK1d/e/a Inhibitor from Pyrazolo-Piperazine Chemotype; To Be Published,

実験手法

X-RAY DIFFRACTION (1.45 Å)