8IVU

Crystal Structure of Human NAMPT in complex with A4276

8IVU の概要

• エントリーDOI: 10.2210/pdb8ivu/pdb
• 分子名称: Nicotinamide phosphoribosyltransferase, N-[[4-(6-methyl-1,3-benzoxazol-2-yl)phenyl]methyl]pyridine-3-carboxamide, PHOSPHATE ION, ... (4 entities in total)
• 機能のキーワード: nampt, transferase, inhibitor, complex, cancer
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 224892.92

構造登録者

Kang, B.G.,Cha, S.S. (登録日: 2023-03-28, 公開日: 2023-10-11)

• 主引用文献: Kim, M.,Kim, H.,Kang, B.G.,Lee, J.,Kim, T.,Lee, H.,Jung, J.,Oh, M.J.,Seo, S.,Ryu, M.J.,Sung, Y.,Lee, Y.,Yeom, J.,Han, G.,Cha, S.S.,Jung, H.,Kim, H.S.; Discovery of a novel NAMPT inhibitor that selectively targets NAPRT-deficient EMT-subtype cancer cells and alleviates chemotherapy-induced peripheral neuropathy.; Theranostics, 13:5075-5098, 2023; PubMed: 37771778; DOI: 10.7150/thno.85356

実験手法

X-RAY DIFFRACTION (2.09000922463 Å)